Peer-reviewed veterinary case report
Boxer dog with cerebellar medulloblastoma tumor and telomerase
By Mandrioli, L et al.·Published in Veterinary pathology·2011·Department of Veterinary Public Health and Animal Pathology, Italy·View original on PubMed →
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Original publication title: Immunohistochemical profiling and telomerase activity of a canine medulloblastoma.
- Species:
- dog
Plain-English summary
A 4-year-old male Boxer was brought in with sudden balance problems and coordination issues, which were found to be caused by a tumor in his brain. A CT scan revealed a mass in the cerebellum, and after he passed away, a necropsy confirmed it was a medulloblastoma, a type of brain tumor. The tumor was made up of abnormal cells that were identified through special tests, indicating they originated from nerve tissue. Unfortunately, due to the aggressive nature of this tumor, the Boxer did not survive.
People also search for: dog brain tumor symptoms · Boxer vestibular syndrome · medulloblastoma treatment in dogs
Abstract
A well-demarcated mass was found by computed tomography in the left cerebellar hemisphere of a 4-year-old male Boxer with acute onset of progressive central vestibular syndrome. At necropsy, the pink, gelatinous mass was in the flocculonodular lobe. Histologically, neoplastic tissue arose from the granular layer of the cerebellar cortex and consisted of sheets of oval to round hyperchromatic cells, consistent with the diagnosis of medulloblastoma. Synaptophysin and neuron-specific enolase immunoreactivity supported the neuronal origin of the neoplastic cells; furthermore, a weak to moderate c-kit expression was detected, as reported in pediatric medulloblastoma. Telomerase activity of tumor cells was demonstrated by immunohistochemistry and by the telomere repeat amplification protocol, suggesting involvement of this enzymatic pathway.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21123861/