Peer-reviewed veterinary case report
Permeability glycoprotein in dog perianal gland tumors
By Pichaiya, Nutchanon et al.·Published in Veterinary Integrative Sciences·2024·View original on Crossref →
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Original publication title: Immunohistochemical study of permeability glycoprotein expression in canine perianal tumors
- Species:
- dog
Plain-English summary
A study looked at perianal gland tumors in dogs, which are often influenced by hormones. Researchers examined 64 tumor samples and found that most were benign adenomas, while some were more serious carcinomas. They discovered that a small number of tumors showed a specific protein (permeability glycoprotein) that can affect how well chemotherapy works. This finding could help veterinarians better understand how these tumors behave and predict how dogs might respond to treatment.
People also search for: dog perianal tumor treatment · canine perianal gland adenoma · chemotherapy for dog cancer
Abstract
Perianal gland tumors are androgenic hormone-dependent and commonly found in dogs. Permeability glycoprotein (PGP) is a member of the ATP-binding cassette transporter family, playing an essential role in reducing intracellular drug concentration and limiting drug cytotoxicity in cancer cells, leading to multi-drug resistance. This study aims to investigate PGP expression patterns in perianal gland tumors. Sixty-four specimens from 64 dogs were histologically classified as perianal gland adenoma (59.38%), perianal gland epithelioma (12.50%), and perianal carcinoma (28.13%). All samples are analyzed for PGP expression using immunohistochemistry, scoring for percentage positivity and intensity. Four cases (6.25%) have a positive expression of PGP with intense cytoplasmic staining. There was a significant difference in the PGP expression pattern among the groups (p=0.01). The expression of PGP may provide valuable insights into disease prognosis and prediction of clinical outcomes of chemotherapy treatment in dogs with perianal gland tumors
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Search related cases →Original publication on Crossref: https://doi.org/10.12982/vis.2025.071