Peer-reviewed veterinary case report
How chromosome changes affect IVF and ICSI pregnancy outcomes
By Shen L et al.·2025·Department of Emergency, China·View original on Europe PMC →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Impact of chromosomal polymorphisms on pregnancy outcomes after in vitro fertilization or intracytoplasmic sperm injection: A systematic review and meta-analysis.
Plain-English summary
This research looked at how small changes in chromosome structure, known as chromosomal polymorphisms (CPs), might affect pregnancy outcomes for couples using assisted reproductive technologies like in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). The study reviewed 16 articles and found that while CPs did not significantly affect miscarriage rates, they were linked to a slight decrease in fertilization rates, good-quality embryo rates, and cleavage rates. This means that while CPs might make it a bit harder to achieve successful fertilization and embryo development, they don't seem to impact the chances of having a miscarriage. Overall, the findings suggest that more research is needed to fully understand how CPs influence pregnancy outcomes.
Abstract
<h4>Objective</h4>Chromosomal polymorphisms (CPs), subtle variations in chromosome structure, have been previously reported in individuals with infertility, particularly among men. This systematic review and meta-analysis aim to analyze associations between CPs and pregnancy outcomes, focusing on spontaneous abortion rates.<h4>Methodology</h4>A comprehensive literature search was conducted across three databases Medline, Google Scholar and Science Direct databases from inception to December 2023 for articles reporting the impact of CPs on selected fertilization and pregnancy outcomes among men/women/couples who had sought assisted reproductive technologies [ART; either <i>in vitro</i> fertilization (IVF) or intracytoplasmic sperm injection (ICSI)]. We applied the inverse variance method for pooled risk ratios (RR) with 95% confidence intervals (CIs).<h4>Results</h4>From an initial 4271 articles, 16 studies met the inclusion criteria. The analysis evaluated CPs in relation to reproductive outcomes, including abortion rates (AR), fertilization rates (FR), cleavage rates (CR), clinical pregnancy rates (CPR), and good-quality embryo rates (GQER). No significant associations were observed between CPs and AR across men, women, or couples, though high heterogeneity suggested variability in study populations. CPs were associated with a modest reduction (7%) in FR (RR 0.93, 95% CI 0.88-0.97, I2 = 67.8; P-value = 0.04), and GQER (RR 0.93, 95% CI 0.89-0.96, I2 = 17.4; P-value = 0.30), and a small but statistically significant reduction CRs (RR 0.98, 95% CI 0.97-0.99, I2 = 0.0; P-value = 0.48).<h4>Conclusions</h4>The study highlights the influence of CPs on certain fertilization and pregnancy outcomes, particularly GQER, FR and CR, while their impact on miscarriage and clinical pregnancy outcomes remains inconclusive. Further large-scale studies are necessary to investigate further associations.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41450996