Peer-reviewed veterinary case report
Platelet-rich plasma infusion helps treat uterine infection
By Ghallab, Rezk S et al.·Published in Reproduction in domestic animals = Zuchthygiene·2023·Department of Theriogenology·View original on PubMed →
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Original publication title: Impact of intrauterine infusion of Platelets-Rich plasma on endometritis and reproductive performance of Arabian mare.
- Species:
- horse
Plain-English summary
A group of 39 Arabian mares with repeated breeding failures due to endometritis (a uterine infection) were treated to improve their chances of pregnancy. The mares were diagnosed with infections and divided into three treatment groups: one received a special treatment using their own platelet-rich plasma (PRP), another group was given antibiotics, and the last group only received a saline solution. The mares treated with PRP had a significant reduction in uterine swelling and a higher pregnancy rate of 70%, compared to just 22% in the control group. This suggests that using PRP could be an effective and affordable way to help mares with endometritis.
People also search for: Arabian mare endometritis treatment · platelet-rich plasma for horse infertility · equine reproductive health solutions
Abstract
Equine endometritis is one of the most common causes of reproduction failure. To achieve better treatment outcomes, different diagnostic methods should be combined. In the current study, 39 repeat breeder mares were subjected to ultrasonography examination to detect excessive accumulation of intrauterine fluids and an abnormal oedema pattern, which revealed that 61.5% of mares were positive. Combined with endometrial cytology by low-volume uterine flush, 47.7% of smears contain neutrophils (more than 2-3 per HPF X100), and microbial culture. 92.3% of mares were infected with different bacterial isolates, such as Escherichia coli, Streptococci, Staphylococcus, Klebsiella pneumoniae, Klebsiella oxytoca, Citrobacter freundii, Providencia alcalifaciens, and Proteus mirabilis. All mares were given saline solution and gravity withdrawal before being given 20 IU of oxytocin (as ecbolic agents). Mares were divided into three groups; Group one (n = 15) received an intrauterine infusion of 20 mL of freshly prepared autologous platelet-rich plasma (PRP) 6 h after breeding, Group two (n = 15) was treated with three doses of systemic Enrofloxacin 5% during the estrus period, and Group three (n = 9) received only uterine lavage and 20 IU of oxytocin. PRP and Enrofloxacin resulted in a significant (p < .05) reduction in endometrial thickness (oedema; 5.05 and 6.74 mm, respectively) and disappearance of intrauterine fluids compared to the control (10.98 mm). Furthermore, PRP (days) and Enrofloxacin (17.89 days) reduced the days to the next oestrus compared to the control (18.58 and 17.89 vs. 21.19 days, respectively). Furthermore, the pregnancy rate improved to reach 70% in the PRP group and 60% in the Enrofloxacin group, while the control remained low at 22%. In conclusion, autologous PRP can be used as a low-cost alternative therapy for modulating the inflammatory process and effectively treating mares' endometritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36807351/