Peer-reviewed veterinary case report
How mannitol affects heart pressure in dogs with mitral valve leak
By Yao, Jingya & Aoki, Takuma·Published in Veterinary medicine and science·2025·Azabu University, Japan·View original on PubMed →
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Original publication title: Impact of Mannitol on Left Atrial Pressure in Dogs With Mitral Regurgitation.
- Species:
- dog
Plain-English summary
A group of dogs with mitral regurgitation (a heart valve problem) was monitored to see how different doses of mannitol, a medication often used to reduce swelling, affected their heart pressure. The dogs were observed for 12 hours, and while low and medium doses didn't show significant changes, the high dose caused a quick spike in heart pressure that returned to normal after about an hour. This suggests that while mannitol can be used in these cases, pet owners and vets should be careful with higher doses, especially in dogs with more severe heart issues.
People also search for: dog mitral regurgitation treatment · mannitol for dogs heart problems · dog heart pressure medication
Abstract
BACKGROUND: Mannitol has been proven effective in treating cerebral oedema, owing to its osmotic diuretic effect. However, its potential to transiently increase plasma volume raises uncertainties about its impact on dogs with mitral avalve insufficiency. OBJECTIVES: This study aimed to investigate the effects of mannitol on haemodynamics and cardiac load in dogs with experimentally induced mitral regurgitation (MR), with a particular focus on the potential adverse effects of high doses of mannitol. METHODS: We used implantable telemetry to monitor MR dogs for 12 consecutive hours, recording and comparing the dynamic changes in their mean left atrial pressure (mLAP) and heart rate at different doses of mannitol (low [0.5 g/kg], medium [1 g/kg] and high [2 g/kg]). RESULTS: Compared with that in the control group, the low- and medium-dose groups demonstrated a proclivity towards increased mLAP after administration, but without statistical significance. The high-dose group exhibited an immediate increase in the mLAP after administration (p < 0.001), followed by a gradual return to baseline 1 h later. CONCLUSIONS: This study provides crucial reference data for the use of mannitol in treating MR. It is particularly important to exercise caution when administering high doses of mannitol to dogs with advanced stages of MR.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40013606/