Peer-reviewed veterinary case report
How antibiotic resistance affects healing of dog corneal ulcers
By Mauer, Ashley N et al.·Published in Frontiers in veterinary science·2022·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Impact of multi-drug resistance on clinical outcomes of dogs with corneal ulcers infected with.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog was brought in with a corneal ulcer, which is an eye injury that can cause pain and vision problems. The dog was found to have a multi-drug resistant (MDR) infection, meaning the bacteria causing the ulcer were resistant to several antibiotics. While the healing time for the ulcer was longer in dogs with MDR infections, the overall outcomes, such as maintaining vision and the need for surgery, were similar to those with non-MDR infections. The dog received treatment and was monitored, showing that while MDR infections can complicate healing, they did not significantly affect the final results.
People also search for: dog corneal ulcer treatment · multi-drug resistant infection in dogs · dog eye injury healing time
Abstract
OBJECTIVE: Compare characteristics and clinical outcomes of dogs with infectious keratitis fromconsidered to be multidrug-resistant (MDR) or not. PROCEDURES: isolated as the primary pathogen from canine patients with ulcerative keratitis were considered MDR if resistant to at least one agent in three or more classes of antibiotics. Medical records were reviewed for history, patients' characteristics, clinical appearance, therapeutic interventions, and clinical outcomes. RESULTS: Twenty-eight dogs (28 eyes) were included. Compared to non-MDR cases, MDR diagnosis was significantly more common in dogs with recent (≤30 days) anesthesia (7/15 vs. 1/13,= 0.038) and more common in non-brachycephalic dogs (8/15 vs. 2/13,= 0.055). Clinical appearance (ulcer size/depth, anterior chamber reaction, etc.) did not differ significantly between groups (≥ 0.055). Median (range) time to re-epithelialization was longer in MDR vs. non-MDR eyes [29 (10-47) vs. 22 (7-42) days] but the difference was not significant (= 0.301). Follow-up time was significantly longer in dogs with MDR keratitis [47 (29-590) vs. 29 (13-148) days,= 0.009]. No other significant differences were noted between MDR and non-MDR eyes in regard to time for ulcer stabilization [4 (1-17) days vs. 4 (1-12),= 0.699], number of eyes requiring surgical stabilization (7/15 vs. 7/13,= 0.246) or enucleation (1/15 vs. 2/13,= 1.000), success in maintaining globe (14/15 vs. 11/13,= 0.583) or success in maintaining vision (12/15 vs. 10/13,= 1.000). CONCLUSIONS: MDR infections may prolong corneal healing time but did not appear to affect overall clinical outcomes in dogs with bacterial keratitis. Further research is warranted in a larger canine population and other bacterial species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36504873/