Peer-reviewed veterinary case report
Radioiodine treatment effects on inflammation proteins
By Glück, Katharina et al.·Published in Journal of feline medicine and surgery·2022·Department of Veterinary Clinical Sciences, Germany·View original on PubMed →
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Original publication title: Impact of radioiodine treatment on acute phase proteins in hyperthyroid cats.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats underwent radioiodine treatment to help manage their condition. After the treatment, blood tests showed that two specific proteins, AGP and SAA, increased significantly, indicating a mild reaction in the body. In some cats, the increase in these proteins was notable, but it wasn't serious enough to cause concern. Overall, the treatment seemed to trigger a mild response in the cats, but they did not show any major health issues as a result.
People also search for: hyperthyroid cat treatment · radioiodine therapy for cats · cat blood test results after treatment
Abstract
OBJECTIVES: The aim of this study was to investigate the impact of radioiodine treatment (RIT) on the acute phase proteins (APPs) serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP) and haptoglobin (Hp) in hyperthyroid cats. METHODS: Between June 2013 and November 2014, 33 hyperthyroid cats without clinical or laboratory signs of inflammatory or neoplastic disease and a body weight >2.5 kg were enrolled. Immediately before, and 12, 36, 72 h and 6 days after RIT, serum samples were obtained for determination of APP concentrations. RESULTS: Both SAA and AGP concentrations changed significantly after RIT. The concentration of AGP increased gradually after treatment with a maximum concentration at the end of the study period (median baseline 398 μg/ml; median 6 days post-RIT 562 μg/ml [ = 0.001]). A relevant >two-fold increase in AGP was seen in 8/33 (24%) cats. SAA concentration increased significantly within 12 h (baseline 9.2 μg/ml; 12 h post-RIT 22.5 μg/ml [ = 0.012]). In 7/33 (21%) cats, a clinically relevant >10-fold increase in SAA was observed. Hp concentration showed no significant change ( = 0.12). CONCLUSIONS AND RELEVANCE: RIT induced a mild, mainly not clinically relevant acute phase reaction (APR). AGP and SAA were useful APPs to determine RIT-induced APR.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34313486/