Peer-reviewed veterinary case report
Impact of serial systemic infection onvirulence factors.
- Journal:
- Future microbiology
- Year:
- 2020
- Authors:
- Arita, Glaucia S et al.
- Affiliation:
- Department of Clinical Analysis & Biomedicine · Brazil
Abstract
To evaluate changes in virulence and pathogenicity approaches fromafter successive passages in a murine model of systemic candidiasis.Phenotypic assays were performed using colonies recovered from animals infected serially, totalizing five passages.A progressive infection was observed along the passages, with increased fungal burden and the presence of greater inflammatory areas in the histopathological findings. Recovered strains exhibited increased filamentation and biofilm abilities, along with modulation of phospholipase and proteinase activities.Repeated contact between yeast and host increased the expression of virulence factors. Furthermore, a correspondence between phenotypic profile and proteomic data obtained previously was observed.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33026881/