Impact of the 1,2,3-triazole compound derived from salicylaldehyde on localized and systemic organ injury in an experimental superior mesenteric artery ischemia/reperfusion model.

Abstract

BACKGROUND: Despite several studies indicating the efficacy of different molecules in preventing ischemia/reperfusion (I/R) damage, the most effective treatment remains unknown. METHODS: This study included 28 male Sprague rats, which were randomly assigned to four equal groups, with seven rats in each group: Group S (Sham), Group C (Control), Group E (Ethanol), and Group T (Triazole). The superior mesenteric arteries of rats in all groups except Group S were exposed and closed with a vascular clamp, and ischemia was induced for one hour. Oxidative stress parameters, ischemia markers, and biochemical tests indicating organ function were examined. RESULTS: The mean total antioxidant status (TAS) value of Group T was significantly higher than those of Groups C and E, while being significantly lower than that of Group S (p=0.001). The mean total oxidant status (TOS) value of Group T was significantly lower than those of Groups C and E and significantly higher than that of Group S (p<0.001). Although the mean oxidative stress index (OSI) value of Group T was markedly lower than those of Groups C and E, no statistically significant difference was observed compared to Group S (p=0.002, p<0.001, and p=0.721, respectively). The mean ischemia-modified albumin (IMA) value of Group T was significantly lower than those of Groups C and E and significantly higher than that of Group S (p<0.001). The mean malondialdehyde (MDA) value of Group T was significantly lower than those of Groups C and E and significantly higher than that of Group S (p<0.001). CONCLUSION: This study represents the first investigation into the effect of a 1,2,3-triazole compound derived from salicylalde-hyde on ischemia/reperfusion injury. The findings provide strong evidence that the 1,2,3-triazole compound significantly enhances the prevention or treatment of experimental I/R injury. We conclude that this triazole derivative may represent a viable therapeutic option for the treatment and prevention of I/R injury, supported by further experimental and clinical research. The triazole is expected to exhibit enhanced protective properties, particularly when solubilized using alternative methods.