Impact of the Timing of Antibiotic Administration on Digestive Colonization with Carbapenemase-Producingin a Murine Model.

Abstract

While antibiotic use is a risk factor of carbapenemase-producing(CPE) acquisition, the importance of timing of antibiotic administration relative to CPE exposure remains unclear. In a murine model of gut colonization by New Delhi metallo-beta-lactamase-1 (NDM-1)-producing, a single injection of clindamycin within at most 1 week before or after CPE exposure induced colonization persisting up to 100 days. The timing of antibiotic administration relative to CPE exposure may be relevant to infection control and antimicrobial stewardship approaches.