Peer-reviewed veterinary case report
Kidney transporter changes and toxin buildup in cats
By Li, Qinghong et al.·Published in Aging·2024·Nestlé, United States·View original on PubMed →
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Original publication title: Impaired renal transporter gene expression and uremic toxin excretion as aging hallmarks in cats with naturally occurring chronic kidney disease.
- Species:
- cat
Plain-English summary
Aging can lead to kidney problems in cats, and a study found that older cats with chronic kidney disease (CKD) had higher levels of certain toxins in their blood compared to healthy cats. Researchers looked at cats aged 6 to 21 years and discovered that specific genes responsible for removing these toxins from the kidneys were not working as well in cats with CKD. This suggests that as cats age, their kidneys may struggle more with filtering out harmful substances. Understanding these changes can help veterinarians better manage kidney disease in older cats.
People also search for: cat kidney disease symptoms · aging cat kidney problems · chronic kidney disease treatment for cats
Abstract
Aging leads to nephron senescence and chronic kidney disease (CKD). In cats, indoxyl sulfate (IxS) has been previously quantified and associated with CKD, and little is known about tubular transporters. Two cohorts of cats aged 6 to 21 years were enrolled. Cohort 1 included 41 colony cats with 28 control and 13 CKD cats. Cohort 2 had 30 privately-owned cats with 10 control and 20 CKD cats. In cohort 1, serum concentrations of IxS, trimethylamine N-oxide (TMAO),-cresol sulfate (PCS), and phenyl sulfate were higher in CKD vs. control cats (all P<0.05). This observation was independently validated in cohort 2. Renal cortical and medullar tissues were collected from a third cohort of cats euthanized for humane reasons unrelated to the study. We provided the evidence that renal tubular transporter genes, OAT1, OAT4, OATP4C1, and ABCC2, but not OAT3, were expressed in the kidneys of cats, and their expressions were downregulated in CKD (all FDR<0.1). Cats and humans share 90.9%, 77.8%, and 82.5% identities in OAT1, OATP4C1, and ABCC2 proteins, respectively. In healthy cats, circulating TMAO and IxS are significantly correlated with age. Our study reveals impaired uremic toxin secretion and tubular transporter expression in cats with CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39729035/