Peer-reviewed veterinary case report
QRS duration linked to heart failure severity in Beagle dogs
By Wang, Y et al.·Published in Physiological research·2011·Department of Echocardiography, China·View original on PubMed →
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Original publication title: Implications of QRS duration in dogs with pacing-induced heart failure.
- Species:
- dog
Plain-English summary
Sixteen Beagle dogs were studied after being fitted with pacemakers and subjected to rapid heart pacing to induce heart failure. After three weeks, the dogs developed congestive heart failure, and researchers found that those with a prolonged QRS duration (a measure of heart electrical activity) had worse heart function and recovery compared to those with a normal QRS duration. By the end of the four-week recovery period, dogs with normal QRS duration showed significant improvement in heart function. This suggests that a prolonged QRS duration could indicate a poorer prognosis for dogs with heart failure.
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Abstract
The objective of this study was to find out the implication of QRS duration in dogs with rapid pacing-induced heart failure. Sixteen Beagle dogs were implanted with transvenous cardiac pacemakers and underwent rapid right ventricular pacing for 3 weeks at 260 bpm to induce heart failure. Dogs were divided into two groups according to the QRS duration: 9 with normal QRS duration (<100 ms) and 7 with prolonged QRS duration (≥100 ms). Cardiac systolic function and size was analyzed by real time 3-dimensional echocardiography and left ventricular dyssynchrony was assessed by speckle tracking strain imaging. Congestive heart failure developed 3 weeks after rapid right ventricular pacing. Dogs with prolonged QRS duration showed more extensive radial strain and circumferential strain dyssynchrony than dogs with normal QRS duration. At the end of 4-week recovery, greater improvement of left ventricular ejection fraction and left ventricular end-systolic volume was detected in dogs with normal QRS duration. The findings suggested that left ventricular dyssynchrony, indicated by a prolonged QRS duration, predicted an unsatisfying recovery in dogs with rapid pacing-induced heart failure. QRS duration had the potential to be a prognostic indicator for dogs with heart failure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21995896/