Peer-reviewed veterinary case report
Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides.
- Journal:
- Clinical and vaccine immunology : CVI
- Year:
- 2012
- Authors:
- Jones, Gareth J et al.
- Affiliation:
- TB Research Group · United Kingdom
Plain-English summary
Researchers have developed a new skin test for cattle that can help tell the difference between cows infected with bovine tuberculosis and those that have been vaccinated against it. This test uses a mix of proteins from the bacteria that cause the disease, along with an additional protein called Rv3020c, which makes the test more accurate. The improved test can still correctly identify vaccinated cows without infection, even if they have received other vaccines. Overall, this new method enhances the ability to diagnose bovine tuberculosis in cattle.
Abstract
A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22301696/