Peer-reviewed veterinary case report
Dog with chronic hepatitis improved after bone marrow stem cell
By L.G. Santos et al.·Published in Arquivo Brasileiro de Medicina Veterinária e Zootecnia·2024·View original on DOAJ →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Improvement of clinical and laboratory parameters in a canine with idiopathic chronic hepatitis after transplantation of allogeneic mesenchymal cells derived from bone marrow - case report
- Species:
- dog
Plain-English summary
A 13-year-old dog with chronic hepatitis (a liver condition) was experiencing weight loss, vomiting, diarrhea, and lethargy. After being diagnosed, she received three treatments with stem cells taken from bone marrow. Following the first treatment, her symptoms improved, and blood tests showed better liver function and increased protein levels. By the six-month follow-up, she continued to show improvement, with further reductions in liver enzyme levels. This case suggests that stem cell therapy could be a safe and effective option for dogs with liver diseases.
People also search for: dog chronic hepatitis treatment · stem cell therapy for dogs · dog vomiting and diarrhea treatment
Abstract
ABSTRACT Chronic hepatitis (CH) is characterized by the replacement of hepatocytes for fibrotic tissue after injury, and treatment is not curative. Stem cell therapy has shown potential to reduce liver fibrosis. This report describes the management of a dog with CH with a mesenchymal cell-based approach. A 13-year old dog was presented with weight loss, vomiting, diarrhea, and lethargy. She was previously diagnosed with CH. Blood analysis showed hypoalbuminemia, increased serum activities of alanine aminotransferase (ALT) and alkaline phosphatase (ALP), and anemia. Three 2.5x106 bone marrow-derived mesenchymal cells transplantations were performed. After the first transplantation, the owner reported an improvement in clinical signs. Biochemistry evidenced a reduction in ALP activity. After the second administration, serum biochemistry showed a decrease in serum ALT and ALP activities, which kept falling after the third transplantation. There was an increase in albumin and total plasmatic proteins concentration. After six months, the dog came back for control and further improvement in clinical signs, new decrease in ALT activity and a mild increase in ALP concentration was observed. Increase in total and plasmatic protein were also observed. Stem cell-based therapy may be considered a promising alternative for liver diseases. It was safe and showed efficacy in this report.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on DOAJ: https://doi.org/10.1590/1678-4162-13115