Peer-reviewed veterinary case report
Improvement of neurological dysfunctions in aphakia mice, a model of Parkinson's disease, after transplantation of ES cell-derived dopaminergic neuronal precursors.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2014
- Authors:
- Chung, Sangmi et al.
- Affiliation:
- Department of Psychiatry and Program in Neuroscience · United States
- Species:
- rodent
Abstract
Parkinson's disease (PD) is characterized by selective death of the substantia nigra dopaminergic neurons, and previously we have shown that aphakia mice, which harbor spontaneous Pitx3 gene mutation, show specific degeneration of the substantia nigra dopaminergic neurons accompanied by behavioral deficits that is reversed by L-DOPA treatment or transplantation of dopaminergic neural precursors. Here, we describe transplantation of dopaminergic neural precursors to a mouse model of PD, an aphakia mouse, followed by behavioral analyses of transplanted mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25173391/