Peer-reviewed veterinary case report
Improved vision in Rpe65-mutant dogs after 9-cis-retinal eye injection
By Gearhart, Patricia M et al.·Published in Archives of ophthalmology (Chicago, Ill. : 1960)·2010·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Improvement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs.
- Species:
- dog
Plain-English summary
A group of Rpe65-mutant dogs, which have a genetic condition affecting their vision, received an injection of a substance called 9-cis-retinal in one eye to see if it could improve their sight. After the injection, five out of seven dogs showed better responses in their eye tests and improved vision. Some dogs even had noticeable improvements in their ability to see flickering lights. While the effects lasted for about ten weeks in one dog, a second injection in two dogs also helped restore their vision. This treatment shows promise for helping dogs with similar vision problems.
People also search for: dog vision problems treatment · Rpe65 mutation in dogs · 9-cis-retinal for dogs vision
Abstract
OBJECTIVE: To determine the efficacy of intravitreal administration of 9-cis-retinal in restoring visual function in Rpe65-mutant dogs. METHODS: Intravitreal injection of 9-cis-retinal was administered in 1 eye of 7 Rpe65-/- dogs at a range of ages. Electroretinogram analysis and testing of visual performance was used to evaluate outcomes after a single injection and in 2 dogs after a second injection in the same eye. RESULTS: In 5 of 7 injected dogs, 9-cis-retinal injection resulted in increased rod electroretinogram responses and improved functional vision. Three injected dogs exhibited increased 33-Hz flicker amplitudes characteristic of cone-mediated responses. Electroretinogram improvement was no longer evident by week 10 postinjection in 1 dog monitored over time. A second injection of 9-cis-retinal was performed in the same eye of 2 of the 7 dogs and also resulted in rescue of visual function. CONCLUSION: Our findings establish that 9-cis-retinoid therapy can restore visual function in a canine model of human disease resulting from RPE65 mutations. CLINICAL RELEVANCE: These positive proof-of-principle results provide support for the development of intravitreal devices for sustained delivery of 9-cis-retinal as a therapy for conditions resulting from failure of the visual cycle.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20837787/