improves the gut microbiome structure and function in AD-like mice.

Abstract

Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. Therefore, we use the over-expressedadeno-associated virus (AAV) animal system with the aim of identifying possible connections. Our results showed that over-expression of circin brain not only influenced the cholinergic system of brain, but also changed the gut microbiota composition as the,,, and [Eubacterium], and the intestinal homeostasis and physiology, and even the gut microbiota trajectory in new born mice. These findings demonstrate a link between circRNA and gut microbiome, enlarge the 'microbiome- transcriptome' linkage library and provide more information on gut-brain axis.