Peer-reviewed veterinary case report
Impulsivity trait in the early symptomatic BACHD transgenic rat model of Huntington disease.
- Journal:
- Behavioural brain research
- Year:
- 2016
- Authors:
- Manfré, Giuseppe et al.
- Affiliation:
- Institute of Medical Genetics and Applied Genomics · Germany
- Species:
- rodent
Abstract
Impulsivity trait was characterized in 3-5 months old BACHD rats, a transgenic model of Huntington disease, using (1) the delay discounting task to assess cognitive/choice impulsivity, and (2) the Differential Reinforcement of Low Rate of Responding task to evaluate motor/action impulsivity. Transgenic animals showed a high level of choice impulsivity and, to a lesser extent, action impulsivity. Our results provide the first evidence that the transgenic BACHD rat (TG5 line) displays impulsivity disorder as early as 3 months old, as described in early symptomatic HD patients, thus adding to the face validity of the rat model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26592164/