Peer-reviewed veterinary case report
In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease.
- Journal:
- EMBO molecular medicine
- Year:
- 2009
- Authors:
- Murphy, Anne N
- Affiliation:
- Department of Pharmacology · United States
Abstract
For many years research in Parkinson's disease (PD) has linked mitochondrial dysfunction with the characteristic loss of dopaminergic neurons of the substantia nigra, accumulation of cytoplasmic inclusions termed Lewy bodies, and motor dysfunction (Henchcliffe & Beal, 2008). The most compelling connection is that Parkinsonism can be observed in both humans and animals following exposure to inhibitors of complex I of the electron transport chain (Betarbet et al, 2002).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20049706/