Peer-reviewed veterinary case report
In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes.
- Journal:
- Mammalian genome : official journal of the International Mammalian Genome Society
- Year:
- 2014
- Authors:
- Lee, Hui-Young et al.
- Affiliation:
- Lee Gil Ya Cancer and Diabetes Institute · South Korea
- Species:
- rodent
Abstract
The world-wide prevalence of obesity and diabetes has increased sharply during the last two decades. Accordingly, the metabolic phenotyping of genetically engineered mouse models is critical for evaluating the functional roles of target genes in obesity and diabetes, and for developing new therapeutic targets. In this review, we discuss the practical meaning of metabolic phenotyping, the strategy of choosing appropriate tests, and considerations when designing and performing metabolic phenotyping in mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24792749/