Peer-reviewed veterinary case report
Carvacrol, cinnamaldehyde, and thymol boost antifungal effects
By Schlemmer, K B et al.·Published in Journal de mycologie medicale·2019·Programa de Pó, Brazil·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: In vitro activity of carvacrol, cinnamaldehyde and thymol combined with antifungals against Malassezia pachydermatis.
- Species:
- dog
Plain-English summary
A study found that certain natural compounds, carvacrol, cinnamaldehyde, and thymol, showed promise in fighting a yeast called Malassezia pachydermatis, which can cause skin and ear infections in dogs. These compounds were tested alongside common antifungal medications like nystatin and miconazole, and some combinations worked particularly well. While these results are encouraging, more research is needed to see how safe and effective these treatments are when used on dogs. If your dog has skin or ear issues, talk to your vet about the best treatment options available.
People also search for: dog skin infection treatment · Malassezia pachydermatis in dogs · antifungal treatment for dog ear infection
Abstract
Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and thymol (THY) alone and in combination with antifungal agents (fluconazole, itraconazole, ketoconazole, clotrimazole, miconazole, terbinafine and nystatin) against M. pachydermatis. The assays were performed according to the Clinical and Laboratory Standards Institute (CLSI), using Sabouraud dextrose broth and checkerboard microdilution. The mean fractional inhibitory concentration index (FICI) showed primary synergies for the combinations carvacrol+nystatin, thymol+nystatin, and carvacrol+miconazole (80%). In conclusion, the results obtained indicate that the phytochemicals tested showed relevant in vitro anti-M. pachydermatis activity. Future in vivo experiments are needed to elucidate the safety and therapeutic potential of these combinations.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31455580/