Peer-reviewed veterinary case report
Mebendazole and fenbendazole effects on dog brain tumor cells in lab
By Lai, S R et al.·Published in Veterinary and comparative oncology·2017·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells.
- Species:
- dog
Plain-English summary
A study found that two medications, mebendazole and fenbendazole, showed promise in killing cancer cells from dogs with gliomas, a type of brain tumor. When tested in the lab, mebendazole was particularly effective at lower doses compared to fenbendazole. Both drugs disrupted the structure of the cancer cells, which is a good sign for their potential use in treating this type of tumor in dogs. However, more research is needed to see how well these treatments work in actual dogs with gliomas.
People also search for: dog brain tumor treatment · mebendazole for canine glioma · fenbendazole cancer in dogs
Abstract
Benzimidazole anthelmintics have reported anti-neoplastic effects both in vitro and in vivo. The purpose of this study was to evaluate the in vitro chemosensitivity of three canine glioma cell lines to mebendazole and fenbendazole. The mean inhibitory concentration (IC) (±SD) obtained from performing the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay after treating J3T, G06-A, and SDT-3G cells for 72 h with mebendazole were 0.030 ± 0.003, 0.080 ± 0.015 and 0.030 ± 0.006 μM respectively, while those for fenbendazole were 0.550  ± 0.015, 1.530 ± 0.159 and 0.690 ± 0.095 μM; treatment of primary canine fibroblasts for 72 h at ICshowed no significant effect. Immunofluorescence studies showed disruption of tubulin after treatment. Mebendazole and fenbendazole are cytotoxic in canine glioma cell lines in vitro and may be good candidates for treatment of canine gliomas. Further in vivo studies are required.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28078780/