Peer-reviewed veterinary case report
Mupirocin spray stops Staphylococcus pseudintermedius bacteria
By Lee, H J & Bae, S G·Published in Polish journal of veterinary sciences·2024·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: In vitro antibacterial and antibiofilm effects of mupirocin spray against Staphylococcus pseudintermedius.
- Species:
- dog
Plain-English summary
A study found that mupirocin spray, an antibiotic, can effectively treat skin infections in dogs caused by Staphylococcus pseudintermedius, a common bacteria. This spray formulation is easier to apply than the traditional ointment, especially for systemic pyoderma, which is a more severe skin infection. The research showed that both 1% and 2% concentrations of the spray worked well to kill bacteria and prevent biofilm formation over a period of 21 days. This means that mupirocin spray could be a convenient and effective option for treating your dog's skin infections.
People also search for: dog skin infection treatment · mupirocin spray for dogs · Staphylococcus pseudintermedius in dogs
Abstract
Mupirocin is an effective antibiotic for infectious skin diseases. However, mupirocin is formulated as an ointment and is difficult to apply in canine systemic pyoderma. Therefore, many clinicians reformulate mupirocin off-label ointment into a spray. This study aimed to evaluate the antibacterial and antibiofilm effects of different concentrations of mupirocin spray (2%, 1%, and 0.5%) onover 21 days. Mupirocin spray was prepared by mixing mupirocin ointment and distilled water. The antibacterial effects were evaluated by measuring the optical density using broth microdilution assay and by live/dead staining. The antibiofilm activity of mupirocin spray was measured using a crystal violet staining method. All concentrations of mupirocin spray inhibited the growth of. Mupirocin spray also inhibited biofilm formation of each isolate, although the degree of inhibition was influenced by the mupirocin concentration. The antibacterial and antibiofilm effects of mupirocin spray were maintained for 21 days. The 2% and 1% mupirocin sprays exhibited significantly better antibacterial and antibiofilm efficacy than the 0.5% mupirocin spray. Thus, 1-2% mupirocin spray may be effective for clinical use. Mupirocin spray is convenient and effective for the treatment of canine systemic pyoderma caused byinfection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39736026/