Peer-reviewed veterinary case report
Monensin antibiotic activity against bacteria in dog ear infections
By Chan, Wei Yee et al.·Published in Comparative immunology, microbiology and infectious diseases·2018·School of Animal and Veterinary Sciences, Australia·View original on PubMed →
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Original publication title: In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa.
- Species:
- dog
Plain-English summary
A study found that monensin, an older drug not used in human medicine, showed effectiveness against certain bacteria causing ear infections in dogs. This is important because some of these bacteria are resistant to multiple antibiotics. Monensin worked well against all Gram-positive bacteria, including tough staph infections, but it didn't affect Gram-negative bacteria or yeast. This suggests that monensin could be a useful option for treating canine ear infections, especially in cases where other antibiotics might not work.
People also search for: dog ear infection treatment · monensin for dog ear infections · antibiotic resistance in dogs
Abstract
Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Multidrug-resistant infections of the canine skin and ear continue to emerge, but the use of antibiotic classes of critical importance to human medicine may not represent good antimicrobial stewardship. Repurposing of old drugs that are not used in human medicine is one approach that addresses both these issues. In this study, the minimal inhibitory concentration (MIC) of monensin for 111 bacterial and yeast canine otitis isolates was determined using microdilution methodology according to Clinical Laboratory Standards Institute (CLSI) guidelines. Monensin was effective against all Gram-positive bacteria including the multidrug-resistant staphylococcal strains with MICs ranging from 1 to 4 μg/ml, but lacked antimicrobial activity against Gram-negative bacteria and yeast isolates. Monensin has potential to be incorporated as one of the main components in an otic formulation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30017076/