Peer-reviewed veterinary case report
Orbifloxacin kills Staph bacteria from dog skin and ear infections
By Ganière, Jean-Pierre et al.·Published in Research in veterinary science·2004·Unité, France·View original on PubMed →
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Original publication title: In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections.
- Species:
- dog
Plain-English summary
A study found that orbifloxacin, an antibiotic, was effective against Staphylococcus intermedius bacteria, which can cause skin and ear infections in dogs. Researchers tested 240 samples from infected dogs and discovered that most strains were sensitive to orbifloxacin, with only one showing resistance. The antibiotic worked best at higher concentrations, effectively killing the bacteria over time. This suggests that orbifloxacin could be a good treatment option for dogs suffering from skin and ear infections caused by this type of bacteria.
People also search for: dog skin infection treatment · ear infection in dogs · orbifloxacin for dog infections
Abstract
The objective of the study was to evaluate the in vitro activity of orbifloxacin against Staphylococcus intermedius strains isolated in France from canine skin and ear infections. The minimum inhibitory concentrations (MICs) of orbifloxacin against 240 field S. intermedius isolates (69 skin and 171 ear isolates) ranged from 0.016 to 8 mg l(-1), with MIC50 and MIC90 equal to 0.5 and 1 mg l(-1), respectively. Only one strain, a pyoderma isolate was resistant (MIC=8 mg l(-1)). Orbifloxacin was tested at different concentrations for killing rate against five isolates obtained from pyoderma cases and against a reference strain (Staphylococcus aureus ATCC 29213). Orbifloxacin expressed a concentration-dependent bactericidal activity against the S. aureus reference strain, but a time-dependent bactericidal activity against S. intermedius. Orbifloxacin induced bactericidal effect against the S. intermedius strains tested with concentrations equal to or two times MIC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15120955/