Peer-reviewed veterinary case report
Antiseptic effectiveness on Staphylococcus pseudintermedius from dog
By Murayama, Nobuo et al.·Published in Veterinary dermatology·2013·ASC Dermatology Service, Japan·View original on PubMed →
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Original publication title: In vitro antiseptic susceptibilities for Staphylococcus pseudintermedius isolated from canine superficial pyoderma in Japan.
- Species:
- dog
Plain-English summary
A study looked at 100 samples of Staphylococcus pseudintermedius, a bacteria that can cause skin infections (pyoderma) in dogs, to see how well it responds to different antiseptics, especially chlorhexidine. The researchers found that most of the bacteria were still sensitive to chlorhexidine, meaning it can be an effective treatment for skin infections in dogs. They also checked for certain genes that could make the bacteria resistant to multiple drugs, but none were found. This suggests that chlorhexidine remains a good option for treating these infections in dogs.
People also search for: dog skin infection treatment · chlorhexidine for dog pyoderma · Staphylococcus pseudintermedius in dogs
Abstract
BACKGROUND: Topical therapy, particularly with chlorhexidine, is becoming increasingly common as a treatment option for canine pyoderma; however, there are limited studies on the susceptibility of Staphylococcus pseudintermedius to chlorhexidine compounds. OBJECTIVES: To determine the in vitro susceptibility of both meticillin-resistant and meticillin-susceptible S. pseudintermedius isolates to chlorhexidine and other antiseptic agents and the presence of multidrug efflux pump genes. SAMPLES: One hundred S. pseudintermedius isolates from 23 initial and 77 recurrent cases of canine pyoderma. METHODS: After bacterial identification and mecA testing, minimal inhibitory concentrations (MICs) of antiseptic agents were determined. Multidrug efflux pump genes, including qacA, qacB and smr, were identified. RESULTS: Of the 100 isolates, 57 were identified as meticillin-resistant S. pseudintermedius. The MIC(90) of chlorhexidine acetate, chlorhexidine gluconate, acriflavine, ethidium bromide and benzalkonium chloride were 1, 1, 2, 0.5 and 2 μg/mL, respectively. Multidrug efflux pump genes qacA, qacB and smr were not detected in any of the isolates. CONCLUSIONS AND CLINICAL IMPORTANCE: The MICs for chlorhexidine and other antiseptics remain low, and multidrug efflux pump genes were not found in the tested isolates.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23331688/