Peer-reviewed veterinary case report
Antiviral effects of GS-441524 and itraconazole against feline
By Doki, Tomoyoshi et al.·Published in Research in veterinary science·2022·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: In vitro antiviral effects of GS-441524 and itraconazole combination against feline infectious peritonitis virus.
- Species:
- cat
Plain-English summary
A study found that a combination of two antiviral medications, GS-441524 and itraconazole, may work better together to fight feline infectious peritonitis virus (FIPV), which causes a serious and often fatal disease in cats. This combination showed a strong synergistic effect, meaning that the two drugs together were more effective at reducing the virus than either drug alone. While this research was conducted in a lab setting, it suggests that using both medications could lead to better treatment options for cats suffering from FIP.
People also search for: cat FIP treatment · GS-441524 for cats · itraconazole for feline infectious peritonitis
Abstract
Feline infectious peritonitis virus (FIPV: virulent feline coronavirus) causes a fatal disease called feline infectious peritonitis (FIP) in wild and domestic cat species. Recent studies identified several antiviral drugs that are effective against FIPV. Drug combination is one of the important strategies in the development of novel treatments for viral infections. GS-441524, a nucleoside analog, and itraconazole, a triazole antifungal drug, have been reported that have antiviral effect against FIPV. This study aims to investigate whether the combination of GS-441524 and itraconazole has synergic antiviral effect against FIPV. The antiviral effect was measured by plaque reduction assay using felis catus whole fatus-4 cell. The plaque reduction of GS-441524 against type I FIPVs increased as the concentration of itraconazole increased. The similar result was obtained for type II FIPV. In addition, the calculated combination index (CI) demonstrated that there was a strong synergy between GS-441524 and itraconazole. It is concluded that the combination of GS-441524 and itraconazole may enhance the individual effect of each drug against replication of type I FIPVs and may contribute to development more effective treatment strategy for FIP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35033848/