Peer-reviewed veterinary case report
Yunnan Baiyao stops growth of dog hemangiosarcoma cells in lab tests
By Wirth, K A et al.·Published in Veterinary and comparative oncology·2016·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines.
- Species:
- dog
Plain-English summary
A study looked at how Yunnan Baiyao, a Chinese herbal medicine, affects hemangiosarcoma (HSA) cells in dogs. Researchers found that this treatment can lead to cell death in HSA cells over time and with higher doses. The results suggest that Yunnan Baiyao may help manage this aggressive cancer in dogs, potentially improving their survival. While this study was done in a lab setting, it supports the idea that Yunnan Baiyao could be beneficial for dogs diagnosed with hemangiosarcoma.
People also search for: dog hemangiosarcoma treatment · Yunnan Baiyao for dogs · herbal medicine for dog cancer
Abstract
Yunnan Baiyao is a Chinese herbal medicine that has been utilized for its anti-inflammatory, haemostatic, wound healing and pain relieving properties in people. It has been utilized in the veterinary profession to control bleeding in dogs with hemangiosarcoma (HSA) and has been anecdotally reported to prolong survival times in dogs with this neoplasm. This study evaluated the in vitro activity of Yunnan Baiyao against three canine HSA cell lines after treatment with increasing concentrations of Yunnan Baiyao (50, 100, 200, 400, 600 and 800 µg mL(-1) ) at 24, 48 and 72 h. Mean half maximum inhibitory concentration (IC50 ) at 72 h for DEN, Fitz, SB was 369.9, 275.9 and 325.3 µg mL(-1) , respectively. Caspase-3/7 activity increased in correlation with the IC50 in each cell line which was confirmed by the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL, APO-BRDU Kit; BD Biosciences, San Jose, CA, USA) assay. VEGF in cell supernatant was also quantified. Overall, the study found that Yunnan Baiyao causes dose and time dependent HSA cell death through initiation of caspase-mediated apoptosis, which supports future studies involving Yunnan Baiyao.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24976212/