Peer-reviewed veterinary case report
In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity.
- Journal:
- Journal of enzyme inhibition and medicinal chemistry
- Year:
- 2012
- Authors:
- Arslan, Mikail et al.
- Affiliation:
- Susurluk Technical Vocational School of Higher Education
Abstract
Serum paraoxonase 1 (EC 3.1.8.1, PON1), a calcium-associated enzyme, has an ability to hydrolyze organophosphate compounds. Related to this property, PON1 has a critical role in antioxidant mechanisms. It is well-known that the enzyme protects LDL from oxidation. In this study we investigated the in vitro inhibitory effects of some drugs. These drugs are oxytocin, dexamethasone, atropine sulphate, gentamicin sulphate, sulfadoxine-trimethoprim, furosemid, metamizole sodium and toldimfos sodium. The IC(50) values obtained varied markedly from 0.014 to 507.72 mg/mL. According to our findings, most potent and significant inhibition was displayed by dexamethasone, atropine sulphate and furosemid.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21985443/