Peer-reviewed veterinary case report
Topical treatments tested against Staphylococcus pseudintermedius
By Valentine, Becky K et al.·Published in Veterinary dermatology·2012·Ontario Veterinary College, Canada·View original on PubMed →
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Original publication title: In vitro evaluation of topical biocide and antimicrobial susceptibility of Staphylococcus pseudintermedius from dogs.
- Species:
- dog
Plain-English summary
A study looked at skin infections in dogs caused by Staphylococcus pseudintermedius, a common bacteria that can be resistant to treatment. Researchers tested how well different topical treatments worked against this bacteria, including triclosan, which was very effective, and grapefruit seed extract, which did not work at all. Most of the bacteria samples were also sensitive to other treatments like mupirocin and fusidic acid. This means that while many options are available, it's important for vets to test which treatment will work best for each specific case.
People also search for: dog skin infection treatment · Staphylococcus pseudintermedius in dogs · mupirocin for dog skin problems
Abstract
BACKGROUND: Staphylococcus pseudintermedius is an important canine pathogen, and the emergence and widespread dissemination of meticillin-resistant strains (MRSP) is of significant concern. Multidrug-resistant infections may require alternative approaches, such as the use of topical therapy. There is minimal information about the in vitro susceptibility of meticillin-susceptible S. pseudintermedius (MSSP) and MRSP to biocides and topical antimicrobials. HYPOTHESIS/OBJECTIVES: The hypothesis was that clinical isolates of MSSP and MRSP would not have universal susceptibility to topical biocides and antimicrobials. The goal of this study was to assess the susceptibility of a collection of S. pseudintermedius isolates to selected antimicrobials and biocides. ANIMALS: The study was performed on clinical isolates of MSSP and MRSP from dogs with skin and soft tissue infections collected throughout North America between 2006 and 2008. METHODS: The minimal inhibitory concentrations (MICs) of chlorhexidine digluconate, benzalkonium chloride, triclosan, accelerated hydrogen peroxide, geranium oil, tea tree oil and grapefruit seed extract were tested for 25 MRSP and 25 MSSP isolates from dogs using the agar dilution method. The MICs of fusidic acid, bacitracin and mupirocin were determined using Etests. RESULTS: Triclosan demonstrated excellent activity against all bacterial isolates, with no growth at the lowest concentration evaluated (MIC ≤ 0.5 μg/mL). Conversely, grapefruit seed extract did not inhibit growth at the highest concentration tested (MIC > 3.84 μg/mL). All isolates were susceptible to mupirocin, fusidic acid and bacitracin. There were no significant differences noted in the range, MIC(50) or MIC(90) between MSSP and MRSP isolates. CONCLUSIONS AND CLINICAL IMPORTANCE: While isolates were susceptible to most of the tested compounds, universal susceptibility to all compounds with potential antimicrobial activity cannot be assumed, and specific testing is required.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23050904/