Peer-reviewed veterinary case report
In Vitro Passive Sensitization of Chopped Guinea Pig Lung by Guinea Pig 7S Antibodies
- Journal:
- The Journal of Immunology
- Year:
- 1964
- Authors:
- Baker, Alan R et al.
- Affiliation:
- Department of Medicine, Harvard Medical School, and the Medical Services, Massachusetts General Hospital · United States
- Species:
- rodent
Abstract
Summary Guinea pig 7S γ-1, but not γ-2, antibodies directed against the same antigenic determinant sensitized chopped guinea pig lung tissue for antigen-induced release of histamine. Thus, in vitro experiments confirm previous in vivo findings that guinea pig 7S γ-1, but not γ-2, antibodies sensitize the guinea pig for passive cutaneous and systemic anaphylaxis. Succinate or maleate markedly enhanced antigen-induced release of histamine from tissue passively sensitized in vitro with γ-1 antibodies. Maximum enhancement was achieved by simultaneous addition of antigen and succinate. Succinate did not enhance hemolysis produced by γ-2 anti-hapten antibodies and complement, nor did it enhance lysis of sheep erythrocytes sensitized with guinea pig anti-sheep erythrocyte antisera.
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Search related cases →Original publication: https://doi.org/10.4049/jimmunol.93.4.525