Peer-reviewed veterinary case report
In Vivo Bioluminescent Monitoring of Parasites in BALB/c Mouse Models of Cutaneous Leishmaniasis Drug Discovery.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2020
- Authors:
- Caridha, Diana et al.
- Affiliation:
- Walter Reed Army Institute of Research · United States
Abstract
Confirming the in vivo efficacy of potential antileishmanial compounds that display in vitro potency and good chemical characteristics is one of the most important steps in preclinical research drug discovery before human clinical trials begin. Here we describe the use of the in vivo bioluminescent monitoring of high and low inocula of luciferase-expressing Leishmania major (L. major) parasites in traditional and more innovative rodent models of in vivo cutaneous leishmaniasis (CL) drug discovery.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31721120/