Peer-reviewed veterinary case report
In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2008
- Authors:
- Moayeri, Mahtab et al.
- Affiliation:
- National Institute of Allergy and Infectious Diseases · United States
- Species:
- rodent
Abstract
We evaluated the in vivo efficacy of three beta-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described beta-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18378717/