Peer-reviewed veterinary case report
Alpha2-adrenoceptor response to medetomidine in cats with idiopathic
By Westropp, Jodi L et al.·Published in American journal of veterinary research·2007·Department of Medicine and Epidemiology, United States·View original on PubMed →
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Original publication title: In vivo evaluation of alpha(2)-adrenoceptors in cats with idiopathic cystitis.
- Species:
- cat
Plain-English summary
A group of 13 cats with feline idiopathic cystitis (FIC) was studied to see how they responded to a medication called medetomidine during stressful situations. The cats were given the medication over eight days, and their heart rates, breathing rates, and other vital signs were monitored. It was found that the cats with FIC had lower respiratory rates compared to healthy cats after receiving the medication. The study suggests that stress and environmental changes can affect how these cats respond to treatment, but no significant differences in blood pressure or sedation levels were observed.
People also search for: cat cystitis treatment · feline idiopathic cystitis symptoms · medetomidine for cats · stress in cats with cystitis
Abstract
OBJECTIVE: To evaluate the in vivo response of alpha(2)-adrenoceptors to medetomidine administration in cats with feline idiopathic cystitis (FIC) during periods of stress and after environmental enrichment. ANIMALS: 13 cats with FIC and 12 healthy cats. Procedures-Cats were subjected to an acute-onset moderate stressor for 8 days. After stress, 20 microg of medetomidine/kg was administered IM on days 1, 3, and 8. Heart rate, blood pressure, pupil diameter, respiratory rate, and level of sedation were evaluated before and after administration of the drug. After day 8, cats were moved to an enriched environment, and tests were repeated on day 35. RESULTS: Heart rate decreased and pupil diameter increased significantly after medetomidine administration in healthy cats, compared with cats with FIC. Cats with FIC had significantly lower respiratory rates. No significant differences in blood pressure or sedation level were found. CONCLUSIONS AND CLINICAL RELEVANCE: Increased plasma catecholamine concentrations during the enrichment phase, which have been reported elsewhere, may have contributed to the differences in alpha(2)-adrenoceptor responses detected in cats with FIC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17269887/