Peer-reviewed veterinary case report
In Vivo Target Validation Using Biological Molecules in Drug Development.
- Journal:
- Handbook of experimental pharmacology
- Year:
- 2016
- Authors:
- Sim, Derek S & Kauser, Katalin
- Affiliation:
- Bayer HealthCare · United States
Abstract
Drug development is a resource-intensive process requiring significant financial and time investment. Preclinical target validation studies and in vivo testing of the therapeutic molecules in clinically relevant disease models can accelerate and significantly de-risk later stage clinical development. In this chapter, we will focus on (1) in vivo animal models and (2) pharmacological tools for target validation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26552401/