Peer-reviewed veterinary case report
High rate of kneecap dislocation in Thai Pomeranian dogs and genetic
By Soontornvipart, K et al.·Published in Veterinary journal (London, England : 1997)·2013·Department of Veterinary Surgery·View original on PubMed →
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Original publication title: Incidence and genetic aspects of patellar luxation in Pomeranian dogs in Thailand.
- Species:
- dog
Plain-English summary
A group of Pomeranian dogs in Thailand showed a high rate of patellar luxation (a condition where the kneecap dislocates) with 75% affected. Researchers looked at genetic factors to see if certain genes were linked to this issue, but found that common collagen genes were not involved. However, they did identify a potential genetic region on chromosome 7 that may play a role in this condition. Understanding these genetic aspects could help in managing and preventing patellar luxation in Pomeranians.
People also search for: Pomeranian patellar luxation treatment · why is my dog limping · Pomeranian knee problems · genetic testing for dog health
Abstract
There is a high incidence of patellar luxation (PL) in Pomeranian dogs from Thailand. DNA samples were collected from 59 dogs originating from 15 families. PL was present in 75% of the dogs with a male:female ratio of 1:1.95. Polymorphic microsatellites situated close to the COL6A1, COL6A3, COL9A1, COL9A2, and COL9A3 genes were analyzed for linkage to the phenotype. Sibling-pair analysis revealed that none of the collagen markers analyzed had a high non-parametric linkage score with the highest score, 1.56, for COL9A2 (P=0.07). The low LOD scores for these collagen genes indicated a non-involvement in the pathogenesis of PL in Pomeranians. An association study with a low density single nucleotide polymorphism (SNP) set indicated the possible involvement of a region on chromosome 7. The association of this region remained indicative when larger groups of 43 cases and 40 controls were compared (Chi square test P=0.01).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22939087/