Peer-reviewed veterinary case report
Allergy antibodies found in atopic dogs from South-East England
By Patel, Anita et al.·Published in The Veterinary record·2019·Dermatology Referrals, United Kingdom·View original on PubMed →
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Original publication title: Incidence of anti-Der f 2 and anti-Zen 1-specific immunoglobulin E antibodies in atopic dogs from South-East England.
- Species:
- dog
Plain-English summary
A group of 59 dogs with non-seasonal skin allergies (atopic dermatitis) from South-East England were tested for specific allergens. Most of these dogs had antibodies against two major allergens, Der f 2 and Zen 1, which are common triggers for their itching and skin problems. The study found that 97% of the dogs had antibodies to Der f 2, while 76% had them for Zen 1. This suggests that both allergens are significant causes of skin issues in these dogs.
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Abstract
Recent studies from North America and continental Europe have reported Zen 1 as a major allergen in atopic dogs, and Der f 2 as a minor allergen. In contrast, Der f 2 is considered a major allergen in Japan. In this study, allergen-specific IgE against Der f 2, Zen 1 and crude(DF) was determined using ELISA assays in English atopic dogs. Serum samples were obtained from 59 dogs with non-seasonal atopic dermatitis. ELISA assays using horseradish peroxidase-labelled anti-dog IgE monoclonal antibody (Bethyl; A40-125P) and recombinant Der f 2 (Zenoaq), natural Zen 1 (Zenoaq) and DF extract (Greer Laboratories; North Carolina) were performed by Zenoaq, Fukushima, Japan. The mean optical density (OD) of each sample was determined and the cut-off value was calculated from OD readings obtained from four healthy control dogs. Der f 2, Zen 1 and DF-specific IgE antibodies were found in the serum samples taken from 57 (97 per cent), 45 (76 per cent) and 47 (80 per cent) atopic dogs, respectively, suggesting that both Zen 1 and Der f 2 are 'major allergens' in the South-East England.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30674643/