Peer-reviewed veterinary case report
Seizure risk after iopamidol or iomeprol myelography in dogs
By Lexmaulova, Leona et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2009·Department of Surgery and Orthopedics·View original on PubMed →
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Original publication title: Incidence of seizures associated with iopamidol or iomeprol myelography in dogs with intervertebral disk disease: 161 cases (2000-2002).
- Species:
- dog
Plain-English summary
A group of 161 dogs with intervertebral disk disease underwent a special imaging procedure called myelography, using either iopamidol or iomeprol as a contrast agent. After the procedure, 23 of the dogs experienced seizures, which is about 14%. The study found that while both contrast agents are generally safe, dogs with severe spinal issues (thoracolumbar disk extrusion) had a higher risk of seizures when iopamidol was used compared to iomeprol. Based on these findings, iomeprol is recommended for use in these specific cases to reduce the risk of seizures.
People also search for: dog seizures after myelography · intervertebral disk disease treatment · iomeprol vs iopamidol for dogs
Abstract
OBJECTIVE: To compare the incidence of seizures in dogs with intervertebral disk disease after iopamidol or iomeprol myelography, and to assess whether the incidence of seizures differed between the 2 agents when severity of neurological deficits, location of cord compression, duration of anesthesia, site of myelogram, volume of contrast, and concentration of contrast were evaluated. DESIGN: Retrospective study. SETTING: Veterinary teaching hospital. ANIMALS: One hundred and sixty-one client-owned dogs with intervertebral disk disease. INTERVENTIONS: Subarachnoid injection of contrast medium. MEASUREMENTS AND MAIN RESULTS: One hundred and sixty-one dogs with intervertebral disk disease were subjected to myelography using iopamidol (n=74) or iomeprol (n=87). Cranial myelography was performed in 31 dogs, caudal myelography in 125 and both cranial and caudal myelography in 5. Seizures occurred in 23 of 161 (14%) dogs. There was no significant difference overall between iopamidol and iomeprol myelography. However, in dogs with thoracolumbar disk extrusion and paraplegia, seizures occurred more frequently after caudal myelography using iopamidol compared with iomeprol. CONCLUSIONS: Both iomeprol and iopamidol are suitable for myelography in dogs. Iomeprol is recommended for caudal myelography in paraplegic dogs with thoracolumbar disk extrusion due to the higher incidence of seizures in this group when iopamidol was used.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20017767/