Peer-reviewed veterinary case report
Sterile bladder bleeding in dogs on cyclophosphamide and furosemide
By Iwaki, Yoshimi et al.·Published in Journal of the American Animal Hospital Association·2022·View original on PubMed →
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Original publication title: Incidence of Sterile Hemorrhagic Cystitis in Dogs Treated with Cyclophosphamide and Low-Dose Furosemide.
- Species:
- dog
Plain-English summary
Eighty-one dogs with lymphoma were treated with a chemotherapy drug called cyclophosphamide, along with a diuretic called furosemide to help prevent bladder issues. After treatment, only two dogs (about 2.5%) showed signs of sterile hemorrhagic cystitis, which is bleeding in the bladder without infection. The use of furosemide at a lower dose was effective in keeping the incidence of this condition low, similar to higher doses used in other studies. Overall, the dogs tolerated the treatment well, with minimal side effects noted.
People also search for: dog lymphoma treatment side effects · sterile hemorrhagic cystitis in dogs · furosemide for dog chemotherapy
Abstract
Cyclophosphamide is a commonly used chemotherapy in the treatment of lymphoma. It can cause sterile hemorrhagic cystitis (SHC), and furosemide is used to decrease the incidence of SHC. The aim of this study is to evaluate the incidence of SHC in dogs treated with a bolus maximum tolerated dose of oral cyclophosphamide and oral furosemide at a dose of 1 mg/kg. Medical records were reviewed to determine the incidence of SHC, dose and number of oral cyclophosphamide treatments, and the dose of furosemide. Other side effects from cyclophosphamide were also recorded. Eighty-one client-owned dogs that received a single oral maximum tolerated dose of cyclophosphamide concurrent with oral furosemide as part of a chemotherapy protocol for lymphoma were included in the study. A total of 252 doses of cyclophosphamide were administered to 81 dogs. The median dose of cyclophosphamide was 239.3 mg/m2. The median dose of furosemide was 1.08 mg/kg. SHC was suspected in 2 dogs (2.46%). Concurrent use of furosemide at a dose of 1 mg/kg with cyclophosphamide yields a similar incidence of SHC than using a higher dose of furosemide as previously reported.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35195711/