Peer-reviewed veterinary case report
Sentinel lymph node mapping changes treatment for dogs with mast cell
By Worley, Deanna R·Published in Veterinary and comparative oncology·2014·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Incorporation of sentinel lymph node mapping in dogs with mast cell tumours: 20 consecutive procedures.
- Species:
- dog
Plain-English summary
A group of 19 dogs with mast cell tumors (a type of skin cancer) underwent a special procedure called sentinel lymph node mapping to help determine if they needed additional treatment after surgery. During the procedure, the veterinarians used a combination of imaging and dye to identify which lymph nodes were most affected by the cancer. As a result, 8 of the dogs were recommended for extra therapy that they wouldn't have received otherwise. This approach helps ensure that dogs with mast cell tumors get the most appropriate care based on their specific situation.
People also search for: dog mast cell tumor treatment · sentinel lymph node mapping dogs · mast cell tumor surgery recovery
Abstract
The study hypothesis is that incorporation of sentinel lymph node (SLN) mapping in dogs presenting for mast cell tumour (MCT) removal would impact the recommended adjuvant therapy offered. Nineteen dogs were enrolled having either spontaneously occurring or incompletely excised MCTs. Staging included regional lymph node aspiration. SLN mapping was done with regional lymphoscintigraphy combined with intra-operative lymphoscintigraphy and blue dye. Twenty MCTs in 19 dogs were excised with SLN mapping. Eight dogs had SLNs different from the closest node. Twelve dogs had metastasis in extirpated SLNs, seven occurred in MCTs with a MI ≤ 5. No correlation was noted between patient stage and the c-KIT proto-oncogene. Because of SLN staging, 8 of 19 dogs were offered additional therapy that would have otherwise been excluded. Anatomic sampling of lymph nodes in dogs with MCTs does not accurately reflect which lymph nodes are most likely to be receiving the draining tumour lymph.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22958227/