Peer-reviewed veterinary case report
Increase in cellular immune responses in Onchocerca-infected cattle after treatment with the microfilaricide, milbemycin.
- Journal:
- Veterinary parasitology
- Year:
- 2006
- Authors:
- Melrose, W D & Copeman, D B
- Affiliation:
- School of Public Health and Tropical Medicine · Australia
Abstract
Lymphocytes from Onchocerca-infected steers treated with the microfilaricide, milbemycin showed increased proliferation when challenged with antigen from Dirofilaria immitis, concanavalin A, tuberculin and tetanus toxoid, compared with untreated animals. This paper confirms that Onchocerca infection induces immunosuppression to filarial and non-filarial antigens. It raises the possibility that filarial-induced immunosuppression may increase the susceptibility to mycobacterial infections and reduce the efficacy of vaccinations and strongly indicates that further research is required.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16229954/