Peer-reviewed veterinary case report
Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits.
- Journal:
- Journal of controlled release : official journal of the Controlled Release Society
- Year:
- 2004
- Authors:
- Lukyanov, Anatoly N et al.
- Affiliation:
- Department of Pharmaceutical Sciences · United States
- Species:
- rabbit
Abstract
Micelles prepared from polyethyleneglycol/phosphatidyl-ethanolamine conjugates (PEG-PE) with a size of 7-20 nm and zeta-potential of approximately -18 mV were administered i.v. to rabbits with experimental myocardial infarctions. Micelles demonstrated a prolonged circulation in the blood (half-life of 2 h) and accumulated in the infarction zone with efficiency more than 8-fold higher as compared to a non-damaged part of the heart muscle. Obtained results suggest that the enhanced permeability and retention (EPR) effect is the primary mechanism of accumulation of microparticles in the infarct areas, and that drug carriers such as PEG-PE micelles can be used for the delivery of therapeutic or diagnostic agents to an area of myocardial infarction.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14684282/