Peer-reviewed veterinary case report
Blood markers of inflammation and anti-fibrosis rise in dogs
By Fonfara, S et al.·Published in Research in veterinary science·2012·Small Animal Teaching Hospital, United Kingdom·View original on PubMed →
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Original publication title: Increased blood mRNA expression of inflammatory and anti-fibrotic markers in dogs with congestive heart failure.
- Species:
- dog
Plain-English summary
A study looked at blood samples from dogs with congestive heart failure (CHF) and found that they had higher levels of certain inflammatory markers compared to healthy dogs. Specifically, dogs with CHF showed increased levels of IL1β and MMP1, which are linked to inflammation and heart tissue remodeling. Understanding these changes could help veterinarians develop better treatments for dogs suffering from heart problems. While the study didn't focus on specific treatments, it highlights the importance of managing inflammation in dogs with CHF.
People also search for: dog congestive heart failure symptoms · dog heart disease treatment · inflammatory markers in dogs
Abstract
Inflammation and extracellular matrix (ECM) remodeling contribute to the development of congestive heart failure (CHF), but the pathogenesis is still incompletely understood. Therefore, whole blood samples from eight dogs without cardiac disease and eight dogs with CHF were investigated for mRNA expression of IL1β, IL2, IL4, IL6, IL8, IL10, TNFα, IFNγ, TGFβ1-3, MMP1, -2, -3, -9 and TIMP1-4 using quantitative PCR. Dogs with CHF had significantly higher IL1β (P=0.015), IL2 (P=0.043), MMP1 (P=0.031), TIMP3 (P=0.012) and lower TNFα (P<0.001), TGFβ3 (P=0.006), TIMP1 (P=0.015) and TIMP2 (P=0.011) mRNA levels. Increased pro-inflammatory IL1β and anti-fibrotic MMP1 and reduced pro-fibrotic TGFβ and TIMP1 and TIMP2 in dogs with CHF suggest progressive left ventricular remodeling. The reduction of TNFα and increase of immunomodulatory IL2 and TIMP3 might suggest control of the inflammatory response. A better understanding of inflammation and ECM remodeling in cardiac diseases may lead to novel treatment approaches.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22100243/