Peer-reviewed veterinary case report
High chymase enzyme activity in heart of dog with pulmonic stenosis
By Fujii, Yoko et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2007·Department of Surgery 1, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Increased chymase-like activity in a dog with congenital pulmonic stenosis.
- Species:
- dog
Plain-English summary
A one-year-old Beagle was diagnosed with congenital pulmonic stenosis, a heart condition that can cause breathing problems and fatigue. Tests showed that this dog's heart had higher levels of certain enzymes compared to healthy Beagles, indicating that the heart was under stress. While the study suggests that further research is needed, it raises the possibility that medications targeting these enzymes might help manage the condition and prevent further heart damage.
People also search for: Beagle congenital heart disease treatment · dog breathing problems · pulmonic stenosis in dogs · heart medication for dogs
Abstract
OBJECTIVES: This study was intended to compare the tissue chymase-like activity and angiotensin converting enzyme (ACE) activity in the right and left ventricles of a dog with congenital pulmonic stenosis (PS), with normal dogs, and to discuss the potential clinical implications of these findings. ANIMALS, MATERIALS AND METHODS: Study subjects included a one-year-old Beagle dog with spontaneous PS and six clinically normal Beagles. Chymase-like and ACE activities were determined in all hearts by high pressure liquid chromatography. RESULTS: In the PS dog right ventricular (RV) chymase-like activity (49.79 nmol/min/g tissue) and left ventricular (LV) chymase-like activity (36.85 nmol/min/g tissue) were elevated vs normal Beagle dogs (mean+/-standard deviation, RV: 20.17+/-5.24 nmol/min/g, LV: 19.03+/-3.27 nmol/min/g). CONCLUSIONS: Activation of the tissue RAA system was detected in a dog with congenital PS. This interesting finding should be pursued with further studies to validate this result, and to explore whether pharmacological blockade of chymase, or the angiotensin II receptor, represents a useful strategy to prevent myocardial remodeling in this condition.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17689467/