Peer-reviewed veterinary case report
Higher TIMP-1 levels linked to better survival in dog skin mast cell
By Pulz, L H et al.·Published in Veterinary and comparative oncology·2017·Departamento de Patologia, Brazil·View original on PubMed →
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Original publication title: Increased expression of tissue inhibitor of metalloproteinase-1 correlates with improved outcome in canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at dogs with skin tumors called mast cell tumors (MCTs) to see how certain proteins affected their survival after surgery. It found that dogs with higher levels of a protein called TIMP-1 had better outcomes and lived longer after their tumors were removed. Specifically, dogs with less than 22.9% positivity for TIMP-1 were more likely to have a shorter life after surgery. This suggests that checking TIMP-1 levels could help predict how well a dog will do after treatment for MCTs.
People also search for: dog mast cell tumor prognosis · canine skin tumor treatment · mast cell tumor survival rate
Abstract
Canine mast cell tumour (MCT) is a biologically heterogeneous disease. The extracellular matrix degradation promoted by matrix metalloproteinases (MMPs) has been studied in an attempt to elucidate the mechanisms involved in the biological behaviour of tumours. The aim of this study was to characterize the expression of MMP-2 and -9 and tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in canine cutaneous MCTs and to evaluate their prognostic values. Immunohistochemical staining for MMP-2, MMP-9, TIMP-2 and TIMP-1 was performed in 46 canine cases of MCTs. TIMP-1 expression showed an independent prognostic value for post-surgical survival and disease-related mortality. Dogs with MCTs showing less than 22.9% mast cell TIMP-1 positivity were more prone to die because of the disease and had a shorter post-surgical survival. This article suggests the involvement of TIMP-1 in MCT progression, by contributing to a good outcome in patients with MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27041588/