Peer-reviewed veterinary case report
Increased GABA signaling in liver macrophage promotes HBV replication in HBV-carrier mice.
- Journal:
- Virus research
- Year:
- 2024
- Authors:
- Chen, Yunling et al.
- Affiliation:
- Shandong First Medical University & Shandong Academy of Medical Sciences · China
- Species:
- rodent
Abstract
Gamma-aminobutyric acid (GABA) signals in various non-neuronal cells including hepatocytes and some immune cells. Studies, including ours, show that type A GABA receptors (GABARs)-mediated signaling occurs in macrophages regulating tissue-specific functions. Our recent study reveals that activation of GABARs in liver macrophages promotes their M2-like polarization and increases HBV replication in mice. This short article briefly summarizes the GABA signaling system in macrophages and discusses potential mechanisms by which GABA signaling promotes HBV replication.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38548137/