Peer-reviewed veterinary case report
Genetic risk for thyroid autoimmune disease in Giant Schnauzers
By Wilbe, M et al.·Published in Tissue antigens·2010·Department of Animal Breeding and Genetics·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Increased genetic risk or protection for canine autoimmune lymphocytic thyroiditis in Giant Schnauzers depends on DLA class II genotype.
- Species:
- dog
Plain-English summary
Giant Schnauzers may be at higher risk for autoimmune thyroiditis, a condition similar to Hashimoto's thyroiditis in humans. Certain genetic markers in these dogs can either increase the likelihood of developing this disease or offer protection against it. Specifically, those with the DLA-DRB1*01201 haplotype are more prone to the condition, while those with the DLA-DRB1*01301 haplotype may be protected. Understanding these genetic factors can help veterinarians assess risk and tailor preventive care for affected breeds.
People also search for: Giant Schnauzer thyroid disease symptoms · autoimmune thyroiditis in dogs · dog genetic risk factors for thyroid problems
Abstract
Dogs represent an excellent comparative model for autoimmune thyroiditis as several dog breeds develop canine lymphocytic thyroiditis (CLT), which is clinically similar to Hashimoto's thyroiditis in human. We obtained evidence that dog leukocyte antigen (DLA) class II genotype function as either genetic risk factor that predisposes for CLT or as protective factor against the disease. Genetic diversity at their DLA-DRB1, -DQA1, and -DQB1 loci were defined and potential association to major histocompatibility complex II haplotypes and alleles was analyzed. Giant Schnauzers carrying the DLA-DRB1*01201/DQA1*00101/DQB1*00201 haplotype showed an increased risk (odds ratio of 6.5) for developing CLT. The same risk haplotype has, to date, been observed in three different breeds affected by this disease, Giant Schnauzer, Dobermann, and Labrador Retriever, indicating that it is a common genetic risk factor in a variety of breeds affected by this disease. Importantly, protection for development of the disease was found in dogs carrying the DLA-DRB1*01301/DQA1*00301/DQB1*00501 haplotype (odds ratio of 0.3).
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20210920/