Peer-reviewed veterinary case report
Higher leukotriene B4 and enzyme levels in blood cells of dogs
By Breathnach, R et al.·Published in Veterinary journal (London, England : 1997)·2006·Department of Small Animal Clinical Studies·View original on PubMed →
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Original publication title: Increased leukotriene B(4) production, complement C3 conversion and acid hydrolase enzyme concentrations in different leucocyte sub-populations of dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of 31 dogs with atopic dermatitis (a skin allergy) showed increased levels of certain inflammatory markers in their blood compared to healthy dogs. Specifically, these dogs had higher production of leukotriene B(4), which is involved in inflammation, and increased concentrations of specific enzymes related to the inflammatory response. The findings suggest that dogs with atopic dermatitis have a heightened inflammatory response, which could be important for understanding their condition better. Further research is needed to explore how treatments targeting these inflammatory markers might help manage atopic dermatitis in dogs.
People also search for: dog skin allergy treatment · atopic dermatitis in dogs · inflammatory response in dogs
Abstract
Various markers of the inflammatory response were measured in peripheral blood mononuclear cells (PBMCs) and polymorphonuclear neutrophils (PMNs) from 31 dogs with atopic dermatitis (AD). The variables assayed included chemiluminescence, acid hydrolase enzyme concentrations, leukotriene B(4) (LTB(4)) production and complement C3 conversion. The results were compared to those derived from a population of clinically healthy dogs. Dogs with AD exhibited a significant increase in median LTB(4) production in PMNs compared to controls (0.94 versus 0.00 ng/10(6) cells; P<0.01). Significant increases in the median concentrations of intracellular beta-galactosidase (PBMC fraction - 0.42 versus 0.25 mU/10(6) cells; P<0.05) (PMN fraction - 0.47 versus 0.12 mU/10(6) cells; P<0.01) and beta-glucuronidase (PBMC fraction - 0.52 versus 0.27 mU/10(6) cells; P<0.05) were also evident in the AD group. Although median maximum chemiluminescence values for both leucocyte sub-populations were higher in controls, the differences recorded were not significant (P>0.05). However, the median time taken to reach maximum chemiluminescence was significantly shorter in the PMN fraction of dogs with AD (7.00 versus 10.00 min; P<0.01). Atopic dogs had a significant increase in the median percentage conversion of complement C3 to C3b (66.0 versus 57.3%; P<0.01). The results of this study indicate a priming of the inflammatory response in dogs with AD. The role of LTB(4) in the pathogenesis of canine AD and the potential efficacy of leukotriene antagonists in the treatment of this disorder warrant further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16427587/