Peer-reviewed veterinary case report
Higher CD34+ blood cells found in dogs with atopic dermatitis
By Bruet, Vincent et al.·Published in Veterinary Dermatology·2014·Unité Dermatologie, Parasitologie, Mycologie LUNAM, ONIRIS – Nantes‐Atlantic National College of Veterinary Medicine, Food Science and Engineering NANTES Loire Atlantique France, France·View original on Crossref →
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Original publication title: Increased numbers of peripheral blood CD34+ cells in dogs with canine atopic dermatitis
- Species:
- dog
Plain-English summary
A group of dogs with nonfood-induced atopic dermatitis (NFICAD) showed higher levels of certain blood cells (CD34+ cells) compared to healthy dogs and those with other skin issues. These CD34+ cells are thought to be involved in skin allergies, but the study found no direct link between the number of these cells and the severity of itching or skin problems in the affected dogs. While this research suggests that CD34+ cells may play a role in atopic dermatitis, more studies are needed to understand their exact function.
People also search for: dog itching treatment · atopic dermatitis in dogs · CD34+ cells in dogs
Abstract
BackgroundThe bone marrow may be involved in human atopic diseases, as shown by the release of CD34+ cells into the peripheral blood.Hypothesis/ObjectivesThe aim was to determine the numbers of CD34+ cells in atopic dogs.AnimalsThe following three groups of dogs were studied: 27 dogs with nonfood‐induced atopic dermatitis (NFICAD); 16 dogs with nonallergic inflammatory diseases; and 13 healthy control dogs.MethodsDogs with NFICAD were selected after fulfilment of Favrot's criteria and exclusion of other pruritic dermatoses, including flea infestation and adverse reaction to foods. The Canine Atopic Dermatitis Extent and Severity Index (CADESI)‐03 and a Visual Analog Scale (VAS) score for pruritus were used to quantify clinical signs. A phycoerythrin‐conjugated anticanine CD34 antibody was used to stain peripheral blood CD34+ cells, and these were enumerated using a flow cytometer. The CD34+ cell counts were compared between groups and tested (in the NFICAD group) for correlation with the severity of clinical signs.ResultsThe numbers of peripheral CD34+ cells in dogs with NFICAD (median 1.7) were statistically higher than in dogs with other nonallergic inflammatory diseases (median 1.0; P = 0.01) and healthy control dogs (median 0.9; P = 0.009). In dogs with NFICAD, there was no correlation between CD34+ cell numbers and CADESI‐03 scores or owner‐assessed pruritus (VAS score).Conclusions and clinical importanceThe results of this study suggest the possible involvement of CD34+ cells in dogs with NFICAD. The role of CD34+ cells in the aetiopathogenesis of canine atopic dermatitis remains to be determined.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vde.12191