Peer-reviewed veterinary case report
Higher adiponectin levels found in dogs with hypothyroidism
By Mazaki-Tovi, Michal et al.·Published in Veterinary journal (London, England : 1997)·2015·Koret School of Veterinary Medicine·View original on PubMed →
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Original publication title: Increased serum concentrations of adiponectin in canine hypothyroidism.
- Species:
- dog
Plain-English summary
A group of dogs with hypothyroidism had higher levels of a protein called adiponectin in their blood compared to healthy dogs. This increase in adiponectin may be linked to other issues like high cholesterol and insulin resistance, which can occur in dogs with low thyroid hormone levels. If your dog has been diagnosed with hypothyroidism, it's important to monitor their overall health, including cholesterol levels, as these can be affected by their condition. Treatment for hypothyroidism typically involves hormone replacement therapy, which can help manage symptoms and improve overall health.
People also search for: dog hypothyroidism symptoms · high cholesterol in dogs · dog thyroid medication
Abstract
Serum concentrations of adiponectin were compared between sex-matched hypothyroid (n = 18) and euthyroid (n = 18) client-owned dogs with comparable ages and body condition scores (BCS). Concentrations of adiponectin (mean; 95% confidence interval) were significantly (P < 0.01) higher in hypothyroid (17.2 µg/mL; 12.1-20.5 µg/mL) than healthy (8.0 µg/mL; 5.6-11.4 µg/mL) dogs following adjustment for potential confounders (BCS, age and sex). Serum concentrations of adiponectin were significantly negatively associated with concentrations of total thyroxine (P <0.05) and positively correlated with concentrations of cholesterol (r = 0.6, P <0.01) in hypothyroid dogs. In conclusion, this study demonstrated increased serum concentrations of adiponectin in dogs with hypothyroidism. Suggestive of the presence of resistance to adiponectin that could have contributed to development of hyperlipidemia and insulin resistance in these dogs or alternatively, could be a consequence of these metabolic alterations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25555336/